Can an M2 Ultra 64GB Mac run Qwen2.5 72B?
M2 Ultra ยท 64 GB unified memory ยท 800 GB/s ยท Mac Studio (M2 Ultra), Mac Pro (M2 Ultra)
Qwen2.5 72B at Q4_K_M needs about 46.8 GiB against roughly 54.4 GiB usable โ that is 86% of your budget. It will load, but close your browser first, keep the context short, and expect memory pressure. Around 14 tokens/sec.
Where the memory goes
Three things occupy memory when a model is loaded: the weights themselves, the KV cache that holds the conversation, and the runtime's own working buffers. Only the first is fixed โ the KV cache grows with every token in your context.
| Quantisation | Weights | Total | Tok/s | Fits? |
|---|---|---|---|---|
| FP16 | 135.4 GiB | 145.5 GiB | 4 | No |
| Q8_0 | 71.9 GiB | 78.8 GiB | 8 | No |
| Q6_K | 55.9 GiB | 62.0 GiB | 11 | No |
| Q5_K_M | 48.2 GiB | 54.0 GiB | 12 | Yes, but tight |
| Q4_K_M | 41.5 GiB | 46.8 GiB | 14 | Yes, but tight |
| Q3_K_M | 33.0 GiB | 38.0 GiB | 18 | Yes, comfortably |
| Q2_K | 25.4 GiB | 30.0 GiB | 23 | Yes, comfortably |
The default. Best quality-per-gigabyte for most people.
How long a context fits
The KV cache is often what breaks a setup that looked fine at load time. Quantising it to 8-bit roughly halves its footprint with little measurable quality cost.
| Context | KV cache | Total | FP16 KV | Q8 KV |
|---|---|---|---|---|
| 2K | 0.6 GiB | 44.7 GiB | Yes, comfortably | Yes, comfortably |
| 4K | 1.3 GiB | 45.4 GiB | Yes, comfortably | Yes, comfortably |
| 8K | 2.5 GiB | 46.8 GiB | Yes, but tight | Yes, comfortably |
| 16K | 5.0 GiB | 49.6 GiB | Yes, but tight | Yes, but tight |
| 32K | 10.0 GiB | 55.2 GiB | No | Yes, but tight |
| 128K | 40.0 GiB | 88.8 GiB | No | No |
What to run instead on an M2 Ultra 64GB Mac
These are the largest models that fit comfortably on this machine at Q4_K_M with an 8K context.
| Model | Size | Total | Tok/s | |
|---|---|---|---|---|
| DeepSeek-R1-Distill-Llama-70B | 70.6B | 45.6 GiB | 15 | Yes, comfortably |
| Llama 3.3 70B | 70.6B | 45.6 GiB | 15 | Yes, comfortably |
| Mixtral 8x7B | 46.7B | 29.8 GiB | 51 | Yes, comfortably |
| DeepSeek-R1-Distill-Qwen-32B | 32.8B | 22.4 GiB | 32 | Yes, comfortably |
| Qwen2.5 32B | 32.8B | 22.4 GiB | 32 | Yes, comfortably |
| Qwen2.5-Coder 32B | 32.8B | 22.4 GiB | 32 | Yes, comfortably |
How to run it
Ollama is the shortest path. It picks a quantisation automatically โ usually Q4_K_M, which is what the numbers above assume.
brew install ollama
ollama serve &
ollama run qwen2.5:72b
For MLX โ Apple's own array framework, typically a little faster than llama.cpp on Apple Silicon:
pip install mlx-lm
mlx_lm.generate --model mlx-community/Qwen2-5-72B-4bit --prompt "Hello"
sudo sysctl iogpu.wired_limit_mb=55705. This resets on reboot. Quantising the KV cache (--kv-cache-type q8_0 in llama.cpp) buys back 1.2 GiB.Macs that run Qwen2.5 72B comfortably
The smallest configuration that handles it is the M2 Max 96GB (MacBook Pro 16" (M2 Max)).
| Mac | Memory | Bandwidth | Tok/s |
|---|---|---|---|
| M2 Max 96GB | 96 GB | 400 GB/s | 7 |
| M3 Ultra 96GB | 96 GB | 819 GB/s | 15 |
| M3 Max 128GB | 128 GB | 400 GB/s | 7 |
| M4 Max 128GB | 128 GB | 546 GB/s | 10 |
| M2 Ultra 192GB | 192 GB | 800 GB/s | 14 |
| M3 Ultra 256GB | 256 GB | 819 GB/s | 15 |
| M3 Ultra 512GB | 512 GB | 819 GB/s | 15 |
Common questions
- Can an M2 Ultra 64GB Mac run Qwen2.5 72B?
- Yes. At Q4_K_M it needs about 46.8 GiB of the roughly 54.4 GiB available, generating around 14 tokens per second.
- How fast is Qwen2.5 72B on an Mac?
- Around 14 tokens per second. Token generation on Apple Silicon is limited by memory bandwidth, and this machine has 800 GB/s.
- How much memory does Qwen2.5 72B need?
- 41.5 GiB for the weights at Q4_K_M, plus 2.5 GiB for an 8K-token KV cache and about 2.9 GiB of runtime overhead โ 46.8 GiB in total.